• Users Online: 103
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2021  |  Volume : 7  |  Issue : 1  |  Page : 72-76

Is There A Need to Supplement Transfusion-Dependent Thalassemics with Vitamin B12?


1 Department of Pediatrics, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi, India
2 Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi, India

Correspondence Address:
Shilpa K. Arora
Associate Professor, Department of Pediatrics, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, Baba Kharag Singh Marg, New Delhi - 110001
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mamcjms.mamcjms_6_21

Rights and Permissions

Purpose: The aim of this study was to compare the levels of serum vitamin B12 of transfusion-dependent thalassemic (TDT) children with that of healthy controls. The other objectives were to compare the occurrence of vitamin B12 deficiency in cases and controls and to find out any correlation between serum vitamin B12 of cases with their clinical, hematological, and laboratory parameters. This study was proposed as routine supplementation with folic acid is advised in TDT, but there are no guidelines for screening and supplementation of vitamin B12 for these patients. Methods: Thirty TDT children under 18 years and an equal number of age- and sex-matched controls were evaluated. Results: The mean levels of vitamin B12 in TDT group (260.17 ± 86.26 pg/mL) were lower than that of controls (337 ± 213 pg/mL) (P = 0.57). Correlation analysis of serum vitamin B12 levels with several parameters did not reveal any significant result. Conclusions: Similar large-scale multicentric studies are warranted before formulating guidelines for vitamin B12 screening and supplementation in thalassemics. Till then it may be prudent that TDT must be regularly screened for deficiency if the resources permit or else they must be routinely supplemented.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed314    
    Printed4    
    Emailed0    
    PDF Downloaded34    
    Comments [Add]    

Recommend this journal