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ORIGINAL ARTICLE
Year : 2020  |  Volume : 6  |  Issue : 2  |  Page : 107-112

A Cross-Sectional Study Evaluating Inflammatory Markers in Hemophilia and Association with Chronic Complications


1 Department of Medicine, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, India
2 Department of Microbiology, Lok Nayak Hospital, Maulana Azad Medical College, New Delhi, India
3 Pulmonary Medicine, Safdarjung Hospital, New Delhi, India
4 Department of Gastroenterology, PGIMER, Chandigarh, India

Correspondence Address:
Senior Resident Jahnvi Dhar
Department of Gastroenterology, PGIMER, Chandigarh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/mamcjms.mamcjms_95_19

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Introduction: Inflammatory markers in hemophilia have been implicated in various bleeding-related complications such as hemarthrosis and muscle hematoma causing damage to the joints and muscle and overt bleeding episodes. Materials and Method: This cross-sectional study included 30 patients of hemophilia with acute bleeding episode (less than 48 hours) and 30 patients in non-bleeding group (more than 2 weeks). Hemoglobin, leucocyte count, platelet count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), serum albumin, serum fibrinogen, serum ferritin, serum lactate dehydrogenase (LDH), tumour necrosis factor alpha (TNF-α) and IL 1β levels in all the subjects was measured and a correlation was sought between the two groups and with the complications of the disease. Results: ESR, CRP, Fibrinogen, LDH, Ferritin, TNF-α and Interleukin (IL)-1β was higher in acute Bleeder group as compared to Non-bleeder group. The hemophilic patients with joint deformity had elevated ESR and IL-1β. Conclusion: In hemophilia patients, CRP, ESR, Fibrinogen, Ferritin, LDH, IL-1β and TNF-α may have a role as an acute bleeding marker. ESR and IL 1 beta may be markers of arthropathy in hemophilia suggesting that inflammation may have a vital role in hemophilic arthropathy.


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