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Year : 2017  |  Volume : 3  |  Issue : 3  |  Page : 133-139

Changes in Gut Microbiota During Lifespan

Medical Clinic Department, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil

Correspondence Address:
Fernanda de Pace
Tessália Vieira de Camargo Street, 126, 13083887 Campinas, São Paulo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/mamcjms.mamcjms_40_17

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Being able to communicate and modulate host metabolism, the tens of trillions of bacteria that inhabit our gut have been shown to affect traits, which vary from host’s gene expression to behavior, being responsible for maintaining health and exerting influence on the development of a number of diseases. This review shows the changes that occur in the gut microbiota composition along the lifespan, and how the communication with the immune system and central nervous system can be modified as years go by. These changes, most of the times, favor the appearance of inflammatory signals (in older adults), and may contribute to the development of neurodegenerative diseases. Finally, there is a consideration of manipulating the gut microbiota with probiotic therapy as an important option to prevent and treat diseases related to gut microbiota modifications.

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